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3-(Piperazin-1-yl)-1H-indazole hydrochloride → N-(4-{2-[4-(1H-indazol-3-yl)-piperazin-1-yl]-ethyl}-2-methyl-phenyl)-acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(Piperazin-1-yl)-1H-indazole hydrochloride | HCID 21963434 | — |
| 反応物 | N-[4-(2-Chloro-ethyl)-2-methyl-phenyl]-acetamide | HCID 21963464 | — |
| 生成物 | N-(4-{2-[4-(1H-indazol-3-yl)-piperazin-1-yl]-ethyl}-2-methyl-phenyl)-acetamide | HCID 21963593 | 11% |
反応手順
Starting with N-[4-(2-chloro-ethyl)-2-methyl-phenyl]-acetamide (0.194 g, 0.915 mmol) and 3-piperazin-1-yl-1H-indazole hydrochloride (0.328 g, 1.372 mmol), and following the procedure outlined in Example 501, N-(4-{2-[4-(1H-indazol-3-yl)-piperazin-1-yl]-ethyl}-2-methyl-phenyl)-acetamide was obtained as its hydrochloride salt (0.038 g, 0.101 mmol).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07101886B2 |
| 出典データセット | uspto-grants-2006_09 |
| ORD ID | ord-4c381a7fc2604d56818c0c46585e55e5 |
| 出典メモ | uspto-grants-2006_09 |