2-Butenoyl chloride → HCID 131725912, compound

HRID 2211923Notes

Reaction equation

[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([N:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][C:18]3[CH:23]=[CH:22][C:21]([NH2:24])=[C:20]([CH3:25])[CH:19]=3)[CH2:12][CH2:11]2)=[N:2]1.[CH3:26][CH:27]=[CH:28][C:29](Cl)=[O:30]>>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([N:10]2[CH2:11][CH2:12][N:13]([CH2:16][CH2:17][C:18]3[CH:23]=[CH:22][C:21]([NH:24][C:29](=[O:30])[CH:28]=[CH:27][CH3:26])=[C:20]([CH3:25])[CH:19]=3)[CH2:14][CH2:15]2)=[N:2]1

Participants

Reactant 2

HCID 790802-Butenoyl chloride

HCID 21963168HCID 21963168, compound

Product 1

HCID 131725912HCID 131725912, compoundYield 77.3%

Procedure

Starting with 4-[2-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-2-methyl-phenylamine hydrochlQride (0.60 g, 1.702 mmol) and 3-methyl-acryloyl chloride (0.163 mL, 1.702 mmol) and following the procedure outlined in Example 512, but-2-enoic acid{4-[2-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-2-methyl-phenyl]amide (0.553 g, 1.315 mmol) was obtained. Yield=77%. 100% purity at 254 nM; LCMS (APCI): 421.3 [M+H]+; 1H NMR (400 MHz, DMSO-d6) δ 9.17 (s, 1H), 8.01 (d, J=8.53 Hz, 1H), 7.51 (t, J=8.01 Hz, 1H), 7.38 (t, J=8.01 Hz, 1H), 7.29 (d, J=8.01 Hz, 1H), 7.04 (s, 1H), 6.99 (d, J=8.01 Hz, 1H), 6.70 (dq, J=6.86 Hz, J=15.27 Hz, 1H), 6.15 (d, J=15.32 Hz, 1H), 3.44–3.35 (m, 4H), 3.29 (s, H2O), 2.72-s.58 (m, 6H), 2.57–2.49 (m, 2H), 2.11 (s, 3H), 1.80 (d, J=6.89 Hz, 3H).

Sources & evidence

ORD record: ord-e5d16f52e0bd497ba1c1ef8094616d86
Source dataset: uspto-grants-2006_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07101886B2

Reaction notes

Loading…