3-(1-Piperazinyl)-1,2-benzisothiazole monohydrochloride → HCID 21963407, compound

Participants

Reaction Steps

Starting with N-[2-(2-chloro-acetyl)-5-isopropyl-phenyl]-acetamide (0.30 g, 1.182 mmol), and 3-piperazin-1-yl-benzo[d]isothiazole hydrochloride (0.302 g, 1.182 mmol) and following the procedure as outlined in Example 517, N-{2-[2-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-acetyl]-5-isopropyl-phenyl}-acetamide (0.375 g, 0.859 mmol) was obtained as its hydrochloride salt from treatment with dioxane/HCl(gas). Yield=73%. 100% purity at 254 nM. 1H NMR (400 MHz, DMSO-d6) δ 10.71 (s, 1H), 10.36 (bs, 1H), 8.14 (d, J=8.24 Hz, 1H), 8.09 (d, J=8.24 Hz, 1H), 7.78–7.72 (m, 2H), 7.58 (t, J=7.56 Hz, 1H), 7.45 (t, J=7.56 Hz, 1H), 7.18 (d, J=8.24 Hz, 1H), 5.00 (s, 2H), 4.13–4.01 (m, 2H), 3.68–3.44 (m, 6H), 3.40 (s, H2O), 2.93 (heptet, J=6.95 Hz, 1H), 2.08 (s, 3H), 1.19 (d, J=6.95 Hz, 6H).

Provenance & Evidence