HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridinium hydrochloride → (2'r,4'r,6s,10r,13s)-2'-Acetyl-2',6,10,13-tetramethyl-7,8,10,12,13,14,15,16-octahydrospiro[cyclopenta[a]phenanthrene-17,4'-[1,3]dioxane]-3,5'(6h)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridinium hydrochloride | HCID 21584435 | — |
| Reactant | 2-((6s,10r,13s)-17-Hydroxy-6,10,13-trimethyl-3-oxo-6,7,8,10,12,13,14,15,16,17-decahydro-3h-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate | HCID 67284222 | — |
| Reactant | Ethyl ortho-acetate | HCID 86598186 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | (2'r,4'r,6s,10r,13s)-2'-Acetyl-2',6,10,13-tetramethyl-7,8,10,12,13,14,15,16-octahydrospiro[cyclopenta[a]phenanthrene-17,4'-[1,3]dioxane]-3,5'(6h)-dione | HCID 67286271 | — |
Reaction Steps
2-((6S,10R,13S)-17-hydroxy-6,10,13-trimethyl-3-oxo-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate is dissolved in toluene and heated with 1.5 equivalents of ethyl orthoacetate and a trace of pyridinium hydrochloride. Ethanol is distilled off the reaction mixture to drive it to completion.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08207151B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-34542830f273452c91b5fa7f1bc3d88e |
| Source note | uspto-grants-2012_06 |