Methyl iodide → HCID 21962620, compound

HRID 2211934Notes

Reaction equation

HRID 2211934 reaction equation
C[Mg]Br.[CH3:4]I.[CH3:6][C:7]1[CH:8]=[C:9]([CH:16]=[CH:17][CH:18]=1)[O:10][CH2:11][CH2:12][C:13](=[O:15])[CH3:14]>CCOCC>[CH3:14][C:13]([OH:15])([CH2:12][CH2:11][O:10][C:9]1[CH:16]=[CH:17][CH:18]=[C:7]([CH3:6])[CH:8]=1)[CH3:4]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 21962609HCID 21962609, compoundHCID 178418573HCID 178418573, compound

Product 1

HCID 21962620HCID 21962620, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

To a solution of methyl magnesium bromide in ether (50 mL), prepared from Mg (572 mg, 23.56 mmol) and MeI (3.34 g, 23.56 mmol), was added 4-(3-methylphenoxy)-2-butanone (2.1 g, 11.78 mmol) in 10 mL ether. The solution was stirred at room temperature for 30 minutes, after which quenched with water and dil. Hydrochloric acid. The organic layer was separated, dried over sodium sulfate, filtered through a silica plug. Colorless syrup 1.91 g (83%).

Workup

  1. customafter which quenched with water and dil. Hydrochloric acid
  2. customThe organic layer was separated
  3. dry with materialdried over sodium sulfate
  4. filtrationfiltered through a silica plug

Sources & evidence

ORD record
ord-4d081d66311a48df8470f7a536fb51cc
Source dataset
uspto-grants-2006_09
Patent number
US07101878B1

Reaction notes

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