反应详情

温度

22 °C

To a stirred solution of morpholin-2-ylmethylamine (3.1 g) in methanol (70 ml) under nitrogen was added an ethereal solution of ethyl-α,α,α-trifluoroacetate (5 ml in 20 ml ether) which had been washed with saturated aqueous sodium bicarbonate, water and brine, and dried. The mixture was stirred for 30 min at 22° C. before removal of all volatiles in vacuo. The residue was dissolved in methanol (10 ml) and the volatiles again removed in vacuo to give the title compound as a white crunchy foam (4.9 g).

1. washhad been washed with saturated aqueous sodium bicarbonate, water and brine
2. customdried
3. dissolutionThe residue was dissolved in methanol (10 ml)
4. customthe volatiles again removed in vacuo