反应详情

温度

22 °C

(5-Methyl-2-pyridin-3-yl-1,3-oxazol4-yl)acetic acid lithium hydroxide (12 mg) added. The mixture was stirred at 22° C. for 17 h and heated at 60° C. for 2 h. Ethanol (3 ml) and 2N aqueous sodium hydroxide (1 ml) were added, and stirring was continued at 22° C. for 2 h. The mixture was applied to a sulphonic acid ion exchange cartridge (10 g Isolute SCX) and eluted with methanol followed by 10% triethylamine in methanol. Evaporation of the triethylamine containing fraction gave the title compound as a gum (46 mg).

1. temperatureheated at 60° C. for 2 h
2. stirringstirring
3. waitwas continued at 22° C. for 2 h
4. washeluted with methanol
5. customEvaporation of the triethylamine containing fraction