3-Fluorophenylacetic acid → HCID 21962941, compound

HRID 2211984Notes

Reaction equation

HRID 2211984 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH2:13])[CH2:7]1.[F:18][C:19]1[CH:20]=[C:21]([CH2:25][C:26](O)=[O:27])[CH:22]=[CH:23][CH:24]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH:13][C:26](=[O:27])[CH2:25][C:21]2[CH:22]=[CH:23][CH:24]=[C:19]([F:18])[CH:20]=2)[CH2:7]1

Participants

3

Reactant 2

HCID 676173-Fluorophenylacetic acidHCID 10308229[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methylamine

Product 1

HCID 21962941HCID 21962941, compoundYield 49.9%

Procedure

Example 3 was prepared in an analogous manner to Example 1 using a mixture of Intermediate 1 (0.055 g) and (3-fluorophenyl)acetic acid (0.031 g) to give the title compound (0.041 g).

Workup

  1. customExample 3 was prepared in an analogous manner to Example 1 using

Sources & evidence

ORD record
ord-ab6cd2e4f34e4f66a71bb36879663267
Source dataset
uspto-grants-2006_09
Patent number
US07101882B2

Reaction notes

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