4-(Methylthio)phenylacetic acid → HCID 21962878, compound

HRID 2211986Notes

Reaction equation

HRID 2211986 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH2:13])[CH2:7]1.[CH3:18][S:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][C:27](O)=[O:28])=[CH:22][CH:21]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH:13][C:27](=[O:28])[CH2:26][C:23]2[CH:24]=[CH:25][C:20]([S:19][CH3:18])=[CH:21][CH:22]=2)[CH2:7]1

Participants

3

Reactant 2

HCID 49839124-(Methylthio)phenylacetic acidHCID 10308229[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methylamine

Product 1

HCID 21962878HCID 21962878, compoundYield 32.3%

Procedure

Example 5 was prepared in an analogous manner to Example 1 using a mixture of Intermediate 1 (0.055 g) and 4-(methylthio)phenylacetic acid (0.036 g) to give the title compound (0.028 g).

Workup

  1. customExample 5 was prepared in an analogous manner to Example 1 using

Sources & evidence

ORD record
ord-4b92edcc87c64ec3a239d3927b00fd5b
Source dataset
uspto-grants-2006_09
Patent number
US07101882B2

Reaction notes

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