(3,4-Difluorophenyl)acetic acid → HCID 21962943, compound

HRID 2211987Notes

Reaction equation

HRID 2211987 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH2:13])[CH2:7]1.[F:18][C:19]1[CH:20]=[C:21]([CH2:26][C:27](O)=[O:28])[CH:22]=[CH:23][C:24]=1[F:25]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH:13][C:27](=[O:28])[CH2:26][C:21]2[CH:22]=[CH:23][C:24]([F:25])=[C:19]([F:18])[CH:20]=2)[CH2:7]1

Participants

3

Reactant 2

HCID 69571(3,4-Difluorophenyl)acetic acidHCID 10308229[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methylamine

Product 1

HCID 21962943HCID 21962943, compoundYield 23%

Procedure

Example 6 was prepared in an analogous manner to Example 1 using a mixture of Intermediate 1 (0.055 g) and (3,4-difluorophenyl)acetic acid (0.034 g) to give the title compound (0.0195 g).

Workup

  1. customExample 6 was prepared in an analogous manner to Example 1 using

Sources & evidence

ORD record
ord-b09ba536656c4b749e2ff69b46ab39ef
Source dataset
uspto-grants-2006_09
Patent number
US07101882B2

Reaction notes

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