p-Tolylacetic acid → HCID 21962933, compound

HRID 2211989Notes

Reaction equation

HRID 2211989 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH2:13])[CH2:7]1.[CH3:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][C:26](O)=[O:27])=[CH:21][CH:20]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH:13][C:26](=[O:27])[CH2:25][C:22]2[CH:23]=[CH:24][C:19]([CH3:18])=[CH:20][CH:21]=2)[CH2:7]1

Participants

3

Reactant 2

HCID 248474p-Tolylacetic acidHCID 10308229[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methylamine

Product 1

HCID 21962933HCID 21962933, compound

Procedure

Example 9 was prepared in an analogous manner to Example 1 using a mixture of Intermediate 1 (0055 g) and (4-methylphenyl)acetic acid (0.03 g) to give thetitle compound (0.024 g).

Workup

  1. customExample 9 was prepared in an analogous manner to Example 1 using

Sources & evidence

ORD record
ord-45140b30bbc14cbea5dcf2776efc49b7
Source dataset
uspto-grants-2006_09
Patent number
US07101882B2

Reaction notes

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