(4-Chlorophenyl)acetic acid → HCID 21962833, compound

HRID 2211991Notes

Reaction equation

HRID 2211991 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH2:13])[CH2:7]1.[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][C:26](O)=[O:27])=[CH:21][CH:20]=1>>[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][C:26]([NH:13][CH2:12][CH:8]2[O:9][CH2:10][CH2:11][N:6]([CH2:5][C:4]3[CH:14]=[CH:15][C:16]([Cl:17])=[C:2]([Cl:1])[CH:3]=3)[CH2:7]2)=[O:27])=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 15880(4-Chlorophenyl)acetic acidHCID 10308229[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methylamine

Product 1

HCID 21962833HCID 21962833, compoundYield 75.8%

Procedure

Example 11 was prepared in an analogous manner to Example 1 using a mixture of Intermediate 1 (0.028 g) and (4-chlorophenyl)acetic acid (0.019 g) to give the title compound (0.033 g).

Workup

  1. customExample 11 was prepared in an analogous manner to Example 1 using

Sources & evidence

ORD record
ord-6c03371bdaed4cb6baf601e4b8ace6d5
Source dataset
uspto-grants-2006_09
Patent number
US07101882B2

Reaction notes

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