3,4-Dichlorophenylacetic acid → HCID 21962852, compound

HRID 2211994Notes

Reaction equation

HRID 2211994 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH2:13])[CH2:7]1.[Cl:18][C:19]1[CH:20]=[C:21]([CH2:26][C:27](O)=[O:28])[CH:22]=[CH:23][C:24]=1[Cl:25]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH:13][C:27](=[O:28])[CH2:26][C:21]2[CH:22]=[CH:23][C:24]([Cl:25])=[C:19]([Cl:18])[CH:20]=2)[CH2:7]1

Participants

3

Reactant 2

HCID 798743,4-Dichlorophenylacetic acidHCID 10308229[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methylamine

Product 1

HCID 21962852HCID 21962852, compoundYield 16.2%

Procedure

Example 15 was prepared in an analogous manner to Example 1 using a mixture of Intermediate 1 (0.055 g) and (3,4-dichlorophenyl)acetic acid (0.041 g) to give the title compound (0.015 g).

Workup

  1. customExample 15 was prepared in an analogous manner to Example 1 using

Sources & evidence

ORD record
ord-3d11c947097e47cda651923e640227af
Source dataset
uspto-grants-2006_09
Patent number
US07101882B2

Reaction notes

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