o-Chlorophenylacetic acid → HCID 21963023, compound

HRID 2211995Notes

Reaction equation

HRID 2211995 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH2:13])[CH2:7]1.[Cl:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[CH2:25][C:26](O)=[O:27]>>[Cl:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[CH2:25][C:26]([NH:13][CH2:12][CH:8]1[O:9][CH2:10][CH2:11][N:6]([CH2:5][C:4]2[CH:14]=[CH:15][C:16]([Cl:17])=[C:2]([Cl:1])[CH:3]=2)[CH2:7]1)=[O:27]

Participants

3

Reactant 2

HCID 17124o-Chlorophenylacetic acidHCID 10308229[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methylamine

Product 1

HCID 21963023HCID 21963023, compoundYield 29.3%

Procedure

Example 16 was prepared in an analogous manner to Example 1 using a mixture of Intermediate 1 (0.055 g) and (2-chlorophenyl)acetic acid (0.034 g) to give the title compound (0.025 g).

Workup

  1. customExample 16 was prepared in an analogous manner to Example 1 using

Sources & evidence

ORD record
ord-86c2bcbf3492424e91cbfbfa6530f123
Source dataset
uspto-grants-2006_09
Patent number
US07101882B2

Reaction notes

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