3,5-Bis(trifluoromethyl)phenylacetic acid → HCID 21962814, compound

HRID 2211996Notes

Reaction equation

HRID 2211996 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH2:13])[CH2:7]1.[F:18][C:19]([F:35])([F:34])[C:20]1[CH:21]=[C:22]([CH2:30][C:31](O)=[O:32])[CH:23]=[C:24]([C:26]([F:29])([F:28])[F:27])[CH:25]=1>>[F:18][C:19]([F:34])([F:35])[C:20]1[CH:21]=[C:22]([CH2:30][C:31]([NH:13][CH2:12][CH:8]2[O:9][CH2:10][CH2:11][N:6]([CH2:5][C:4]3[CH:14]=[CH:15][C:16]([Cl:17])=[C:2]([Cl:1])[CH:3]=3)[CH2:7]2)=[O:32])[CH:23]=[C:24]([C:26]([F:27])([F:28])[F:29])[CH:25]=1

Participants

3

Reactant 2

HCID 1235873,5-Bis(trifluoromethyl)phenylacetic acidHCID 10308229[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methylamine

Product 1

HCID 21962814HCID 21962814, compoundYield 38.1%

Procedure

Example 17 was prepared in an analogous manner to Example 1 using a mixture of Intermediate 1 (0.055 g) and [3,5-bis(trifluoromethyl)phenyl]acetic acid (0.054 g) to give the title compound (0.04 g).

Workup

  1. customExample 17 was prepared in an analogous manner to Example 1 using

Sources & evidence

ORD record
ord-a499a92ad8474487a067db42c885e02b
Source dataset
uspto-grants-2006_09
Patent number
US07101882B2

Reaction notes

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