4-Methoxyphenylacetic Acid → HCID 21962978, compound

HRID 2212001Notes

Reaction equation

HRID 2212001 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH2:13])[CH2:7]1.[CH3:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][C:27](O)=[O:28])=[CH:22][CH:21]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH:13][C:27](=[O:28])[CH2:26][C:23]2[CH:24]=[CH:25][C:20]([O:19][CH3:18])=[CH:21][CH:22]=2)[CH2:7]1

Participants

3

Reactant 2

HCID 76904-Methoxyphenylacetic AcidHCID 10308229[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methylamine

Product 1

HCID 21962978HCID 21962978, compoundYield 46.4%

Procedure

Example 22 was prepared in an analogous manner to Example 1 using a mixture of Intermediate 1 (0.028 g) and (4-methoxyphenyl)acetic acid (0.018 g) to give the title compound (0.02 g).

Workup

  1. customExample 22 was prepared in an analogous manner to Example 1 using

Sources & evidence

ORD record
ord-f39b1d9519c843a5bc4166a456b9e6fb
Source dataset
uspto-grants-2006_09
Patent number
US07101882B2

Reaction notes

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