3-Thiophenacetic acid → HCID 21963005, compound

HRID 2212004Notes

Reaction equation

HRID 2212004 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH2:13])[CH2:7]1.[S:18]1[CH:22]=[CH:21][C:20]([CH2:23][C:24](O)=[O:25])=[CH:19]1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH:13][C:24](=[O:25])[CH2:23][C:20]2[CH:21]=[CH:22][S:18][CH:19]=2)[CH2:7]1

Participants

3

Reactant 2

HCID 234043-Thiophenacetic acidHCID 10308229[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methylamine

Product 1

HCID 21963005HCID 21963005, compoundYield 20.3%

Procedure

Example 32 was prepared in an analogous manner to Example 1 using a mixture of Intermediate 1 (0.056 g) and thien-3-ylacetic acid (0.028 g) to give the title compound (0.016 g).

Workup

  1. customExample 32 was prepared in an analogous manner to Example 1 using

Sources & evidence

ORD record
ord-71e0abd46387495bb66d7a7f2e33147e
Source dataset
uspto-grants-2006_09
Patent number
US07101882B2

Reaction notes

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