2-(2-pyrazin-2-yl-1,3-thiazol-4-yl)acetic acid → HCID 21962853, compound

HRID 2212008Notes

Reaction equation

HRID 2212008 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH2:13])[CH2:7]1.[N:18]1[CH:23]=[CH:22][N:21]=[CH:20][C:19]=1[C:24]1[S:25][CH:26]=[C:27]([CH2:29][C:30](O)=[O:31])[N:28]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH:13][C:30](=[O:31])[CH2:29][C:27]2[N:28]=[C:24]([C:19]3[CH:20]=[N:21][CH:22]=[CH:23][N:18]=3)[S:25][CH:26]=2)[CH2:7]1

Participants

3

Reactant 2

HCID 27403442-(2-pyrazin-2-yl-1,3-thiazol-4-yl)acetic acidHCID 10308229[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methylamine

Product 1

HCID 21962853HCID 21962853, compoundYield 52.6%

Procedure

Example 37 was prepared in an analogous manner to Example 1 using a mixture of Intermediate 1 (0.056 g) and (2-pyrazin-2-yl-1,3-thiazol-4-yl)acetic acid (0.044 g) to give the title compound (0.05 g).

Workup

  1. customExample 37 was prepared in an analogous manner to Example 1 using

Sources & evidence

ORD record
ord-bdfdad798e0a42ff81c7b0335b5b2795
Source dataset
uspto-grants-2006_09
Patent number
US07101882B2

Reaction notes

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