4-Mesylphenylacetic acid → N-{[(2S)-4-(3,4-Dichlorobenzyl)morpholin-2-yl]methyl}-2-[4-(methylsulfonyl)phenyl]acetamide

HRID 2212010Notes

Reaction equation

HRID 2212010 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][C@@H:8]([CH2:12][NH2:13])[CH2:7]1.[CH3:18][S:19]([C:22]1[CH:27]=[CH:26][C:25]([CH2:28][C:29](O)=[O:30])=[CH:24][CH:23]=1)(=[O:21])=[O:20]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][C@@H:8]([CH2:12][NH:13][C:29](=[O:30])[CH2:28][C:25]2[CH:24]=[CH:23][C:22]([S:19]([CH3:18])(=[O:20])=[O:21])=[CH:27][CH:26]=2)[CH2:7]1

Participants

3

Reactant 2

HCID 5723454-Mesylphenylacetic acidHCID 10171585(S)-(4-(3,4-Dichlorobenzyl)morpholin-2-YL)methanamine

Product 1

HCID 68880920N-{[(2S)-4-(3,4-Dichlorobenzyl)morpholin-2-yl]methyl}-2-[4-(methylsulfonyl)phenyl]acetamideYield 47.8%

Procedure

Example 39 was prepared in an analogous manner to Example 1 using a mixture of Intermediate 9 (0.055 g) and 4-(methylsulphonyl)phenylacetic acid (0.050 g) to give the title compound (0.045 g).

Workup

  1. customExample 39 was prepared in an analogous manner to Example 1 using

Sources & evidence

ORD record
ord-f670f39908d74c888fcc2ad1738d6b7d
Source dataset
uspto-grants-2006_09
Patent number
US07101882B2

Reaction notes

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