2,6-Difluorophenylacetic acid → HCID 21962935, compound

HRID 2212016Notes

Reaction equation

HRID 2212016 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH2:13])[CH2:7]1.[F:18][C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[C:20]=1[CH2:26][C:27](O)=[O:28]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH:13][C:27](=[O:28])[CH2:26][C:20]2[C:19]([F:18])=[CH:24][CH:23]=[CH:22][C:21]=2[F:25])[CH2:7]1

Participants

3

Reactant 2

HCID 1235852,6-Difluorophenylacetic acidHCID 10308229[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methylamine

Product 1

HCID 21962935HCID 21962935, compoundYield 66.4%

Procedure

Example 52 was prepared in an analogous manner to Example 1 using a mixture of Intermediate 1 (0.055 g) and 2,6-difluorophenylacetic acid (0.035 g) to give thetitle compound (0.057 g).

Workup

  1. customExample 52 was prepared in an analogous manner to Example 1 using

Sources & evidence

ORD record
ord-c176fc6f609a41519736bfa2ecf7eb98
Source dataset
uspto-grants-2006_09
Patent number
US07101882B2

Reaction notes

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