HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2E)-3-(4-Cyanophenyl)-2-propenoic acid → 4-[(E)-3-Oxo-3-((S)-2-((piperidin-1-yl)methyl)pyrrolidin-1-yl)propenyl]benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2E)-3-(4-Cyanophenyl)-2-propenoic acid | HCID 735786 | — |
| Reactant | (S)-1-(pyrrolidin-2-ylmethyl)piperidine | HCID 7022796 | — |
| Product | 4-[(E)-3-Oxo-3-((S)-2-((piperidin-1-yl)methyl)pyrrolidin-1-yl)propenyl]benzonitrile | HCID 58697191 | — |
Reaction Steps
150 mg of the title compound were synthesized as described for (E)-3-(4-bromophenyl)-1-((S)-2-((pyrrolidin-1-yl)methyl)pyrrolidin-1-yl)propenone, using (E)-4-cyanocinnamic acid instead of (E)-4-bromocinnamic acid and 1-(((S)-pyrrolidin-2-yl)methyl)piperidine instead of (S)-2-((pyrrolidin-1-yl)methyl)pyrrolidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07101898B2 |
| Source dataset | uspto-grants-2006_09 |
| ORD ID | ord-37a99e3711974eaf88aa098d9bce058a |
| Source note | uspto-grants-2006_09 |