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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2212038Generated: November 2, 2026

2-Fluoro-5-formylbenzonitrile → (E)-3-(3-Cyano-4-fluorophenyl)acrylic acid

https://huagongshe.com/reaction/2212038

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Fluoro-5-formylbenzonitrileHCID 2769582—
Reactant4-Formylphenyl methanesulfonateHCID 14421293—
Reactant(2E)-3-(4-((Methylsulfonyl)oxy)phenyl)-2-propenoic acidHCID 15726601—
Product(E)-3-(3-Cyano-4-fluorophenyl)acrylic acidHCID 21964122—

Reaction Steps

5.52 g of (E)-3-(3-cyano-4-fluorophenyl)acrylic acid was synthesized as described for (E)-3-(4-(methanesulfonyloxy)phenyl)acrylic acid, using 4-fluoro-3-cyanobenzaldehyde (commercially available at Aldrich) instead of methanesulfonic acid 4-formylphenyl ester.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07101898B2
Source datasetuspto-grants-2006_09
ORD IDord-fcc0565f987147498e1c1adca62d4f14
Source noteuspto-grants-2006_09