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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2212040Generated: November 1, 2026

2-Fluoro-4-(trifluoromethyl)benzaldehyde → 2-Fluoro-4-(trifluoromethyl)cinnamic acid

https://huagongshe.com/reaction/2212040

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Fluoro-4-(trifluoromethyl)benzaldehydeHCID 522929—
Reactant4-Formylphenyl methanesulfonateHCID 14421293—
Reactant(2E)-3-(4-((Methylsulfonyl)oxy)phenyl)-2-propenoic acidHCID 15726601—
Product2-Fluoro-4-(trifluoromethyl)cinnamic acidHCID 5709646—

Reaction Steps

5.12 g of (E)-2-Fluoro-4-(trifluoromethyl)cinnamic acid were synthesized as described for (E)-3-(4-(methanesulfonyloxy)phenyl)acrylic acid using 2-fluoro-4-trifluoromethylbenzaldehyde (commercially available from Aldrich) instead of methanesulfonic acid 4-formylphenyl ester.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07101898B2
Source datasetuspto-grants-2006_09
ORD IDord-240fde7c4bb840ab8df31cec2fff2f65
Source noteuspto-grants-2006_09