Toluene → 0-cyclopropylmethyl N-phenylacetyl-(2,6-dichlorophenyl)-acetamidoxime

Participants

Reaction Conditions

Reaction Steps

5.0 g (18 mmol) of 0-cyclopropylmethyl (2,6-dichlorophenyl)acetamidoxime in 40 ml of toluene were heated to 85° C and admixed with 3.9 g (25 mmol) of phenylacetyl chloride. The mixture was heated at 100° C. for 5 h, cooled, poured into aqueous sodium hydrogen carbonate solution (pH 7) and extracted three times with toluene. The combined extracts were washed with water, dried over sodium sulfate and concentrated under reduced pressure. The crude product (5.6 g) was purified by silica gel chromatography using cyclohexane/ethyl acetate. M.p. 134–135° C.

Provenance & Evidence