HCID 69663378, compound → HCID 69662332, compound

Participants

Reaction Conditions

Reaction Steps

n-Butyllithium in hexanes (0.165 ml, 0.25 mmol) was added dropwise to a stirred solution of (3R*,4R*)-4-benzenesulfonyl-3-methylpentan-1-ol (286 mg, 1.2 mmol) in THF (5 ml) at −78° C. The mixture was warmed to 0° C. over 30 min. and quenched with satd. aqueous NH4Cl and extracted with dichloromethane. The combined organic extracts were dried (Na2SO4) and concentrated to give a mixture syn:anti diastereoisomeric sulfones in a 6:1 ratio respectively.

Provenance & Evidence