4-(Trifluoromethyl)piperidine → HCID 69663224, compound

Participants

Reaction Steps

Sodium cyanoborohydride (78 mg, 1.2 mmol) was added to a stirred solution of the crude 4-benzenesulfonyl-3,3-dimethyl-butyraldehyde (240 mg, 1 mmol) and 4-trifluoromethylpiperidine (321 mg, 2.1 mmol) in methanol (4 ml). The mixture was stirred for 1 hour, quenched with sat. aqueous NaHCO3 and extracted into dichloromethane. The combined organic extracts were dried (Na2SO4) and concentrated. The residue was purified on silica (dichloromethane:methanol) to give the title product.

Provenance & Evidence