Potassium Carbonate → HCID 69663052, compound

Participants

Reaction Conditions

Reaction Steps

2M Potassium carbonate solution (containing tetra-n-butylammonium hydroxide) (0.25 ml) followed by 4-methoxybenzeneboronic acid (0.056 g; 0.37 mmol) was added to a solution of Example 229 (0.095 g; 0.25 mmol) in 1,4-dioxane (6 ml). The solution was deoxygenated with nitrogen at room temperature for 5 minutes. Tetrakistriphenylphosphine palladium(0) (catalytic) was added and the solution stirred for 30 minutes at 80° C. After cooling to room temperature, ethyl acetate was added and the organic phase separated then washed twice with water. The organic layer was dried (MgSO4) and evaporated in vacuo. Purification using an SCX cartridge eluting with 1/9 NH3/MeOH afforded the title compound as a yellow oil (90 mg, 87%).

Provenance & Evidence