Benzenesulfonyl chloride → HCID 69663205, compound

Participants

Reaction Steps

Benzenesulfonyl chloride (90 μL, 0.7 mmol) was added to a solution of 1-(4-benzenesulfonyl-4-methylpentyl)-3-(methylamino)piperidine (0.22 g, 0.65 mmol) and triethylamine (180 μL, 1.3 mmol) in dichloromethane (5 ml). The reaction was stirred at room temperature for 30 minutes. The mixture was diluted with dichloromethane and washed with water (×2). The organic layer was dried (MgSO4) and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel, eluting with 2–5% methanol/dichloromethane, to give the title compound (220 mg, 76%).

Provenance & Evidence