Aluminum(III) Chloride → HCID 57467383, compound

Participants

Reaction Steps

To a solution of ethyl 2-(4-methoxy-2-nitrophenoxy)acetate 11 (1.0 g, 0.004 mol) in 10 mL dichloromethane cooled in an ice-bath was added aluminum chloride (1.6 g, 0.0133 mol) portion wise. The resulting mixture was gradually warmed to room temperature and then refluxed for 4 h. The progress of the reaction was monitored by thin layer chromatography (TLC). The reaction mixture was washed with saturated sodium bicarbonate solution and dried over sodium sulfate to give ethyl 2-(4-hydroxy-2-nitrophenoxy)acetate 12 which was purified by silica gel column chromatography using a gradient of hexane and ethyl acetate.

Provenance & Evidence