3,5-Pyridinedicarboxylic acid, 3,5-diethyl ester → HCID 69652400, compound

Participants

Reaction Steps

Hydrogenate pyridine-3,5-dicarboxylic acid diethyl ester (13.4 g, 60.0 mmol) in EtOH (100 mL) and HOAc (35 mL) with PtO2 (2.7 g, cat.) overnight at room temperature and 60 psi. Filter through celite and concentrated to dryness. Partition between sat. aq NaHCO3 and CHCl3. Extract 3× with CHCl3. Wash with sat. aq NaHCO3, wash with brine, dry over Na2SO4, filter and concentrate to dryness. MS(IS) 231.1 (M+2); Carried on without further purification.

Provenance & Evidence