Dicyclohexylcarbodiimide → HCID 21963707, compound

Participants

Reaction Steps

Combine 1-(3-amino-piperidin-1-yl)-4-phenyl-butan-1-one (250 mg, 1.02 mmol) with 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid (260 mg, 1.02 mmol), 1.3-dicyclohexylcarbodiimide (209 mg, 1.01 mmol) and 1-hydroxybenzotriazole (138 mg, 1.02 mmol) in THF and stir overnight at room temperature. Concentrate and elute over silica gel using THF/dichloromethane to give the desired product (326 mg, 66%). MS(ES): (M+1)+ 484.1, 486.1 m/z.

Provenance & Evidence