HCID 69652414, compound → HCID 86592850, compound

Participants

Reaction Steps

Stir a solution of 3-(9-chloro-3-methyl-4-oxo-5H-isoxazolo[4,3-c]quinolin-5-yl)-5-[(pyridin-3-ylmethyl)-carbamoyl]-piperidine-1-carboxylic acid tert-butyl ester (30 mg, 0.05 mmol) in HCl-saturated HOAc (5 mL) 2 H at room temperature then concentrate to dryness. Dissolve 2× in toluene and concentrate to dryness to yield the title compound (26 mg, 100%) as a white oil as a mixture of cis isomers. MS(IS) 452.1 (M+); HPLC (5–95% (0.1% TFA/CH3CN) in (0.1% TFA/water) in 3.8 min on YMC ODS-A (0.46×50 mm) 5 μL/min; 25° C.) Rt=1.6 (min 100%).

Provenance & Evidence