Diisopropylethylamine → HCID 25234792, compound

Participants

Reaction Steps

480 mg of (E)-3-cyclopentyl-2-(10-methyl-5,5-dioxo-5,10-dihydrophenothiazin-2-yl)acrylic acid, 122 mg of commercial 1-methyl-1H-pyrazol-3-ylamine and 0.76 ml of N,N-diisopropylethylamine are dissolved in 7 ml of dimethylformamide. 571 mg of HATU and 204 mg of HOAT are added, and the mixture is stirred at room temperature for one hour. The reaction mixture is then diluted by addition of 100 ml of ethyl acetate and washed five times with in each case 30 ml of water. The organic phase is dried over MgSO4, and the solvent is then removed under reduced pressure. The residue is purified on silica gel using the mobile phase n-heptane (100%)=>:ethyl acetate (100%). This gives 360 mg of (E)-3-cyclopentyl-2-(10-methyl-5,5-dioxo-5,10-dihydrophenothiazin-2-yl)-N-(1-methyl-1H-pyrazol-3-yl)acrylamide.

Provenance & Evidence