p-Toluenesulfonic acid → 1,3,4-Oxadiazole, 2-phenyl-

Participants

Reaction Conditions

Reaction Steps

A mixture of the benzoic hydrazide (22.5 g, 165 mmol), triethylorthoformate (150 mL) and p-toluenesulfonic acid (300 mg) was heated at 120° C. for 12 h. Excess triethylorthoformate was removed under vacuum and the residue was purified by silica gel column chromatography to produce 2-phenyl-[1,3,4]-oxadiazole (14.5 g).

Provenance & Evidence