HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2212231Generated: October 31, 2026
Isoniazid → 4-(1,3,4-Oxadiazol-2-yl)pyridine
https://huagongshe.com/reaction/2212231
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Isoniazid | HCID 3767 | — |
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Solvent | Ethyl orthoformate | HCID 31214 | — |
| Product | 4-(1,3,4-Oxadiazol-2-yl)pyridine | HCID 775636 | 57,738.301% |
Reaction Steps
A mixture of the isonicotinic hydrazide (13.7 g, 100 mmol), triethylorthoformate (60 mL) and p-toluenesulfonic acid (30 mg) was heated at 130° C. for 12 h. Excess triethylorthoformate was removed under vacuum. The crude was crystallized from ethyl acetate to give 14.8 g of 5-pyridin-4-yl-[1,3,4]oxadiazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07101880B2 |
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| Source dataset | uspto-grants-2006_09 |
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| ORD ID | ord-590153869cc44e74bb08698c5db5cbe0 |
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| Source note | uspto-grants-2006_09 |
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