Ethanamine, 2,2,2-trifluoro- → HCID 21962675, compound

HRID 2212235Notes

Reaction equation

HRID 2212235 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([OH:8])=O.[F:9][C:10]([F:14])([F:13])[CH2:11][NH2:12].CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F>>[F:9][C:10]([F:14])([F:13])[CH2:11][NH:12][C:6]([C:2]1[S:1][CH:5]=[CH:4][CH:3]=1)=[O:8]

Participants

4

Reactant 3

HCID 9773Ethanamine, 2,2,2-trifluoro-HCID 107002-Thiophenecarboxylic acidHCID 2733084Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)2×

Product 1

HCID 21962675HCID 21962675, compound

Procedure

Thiophene-2-carboxylic acid was coupled to trifluoroethyl amine using HBTU utilizing a procedure described in Example 1, Step 2 below except substituting HOBt with HBTU to give thiophene-2-carboxylic acid (2,2,2-trifluoroethyl)amide.

Sources & evidence

ORD record
ord-68e2912edea549a58b4c012cdeec973b
Source dataset
uspto-grants-2006_09
Patent number
US07101880B2

Reaction notes

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