HCID 22292781, compound → HCID 9990681, compound

HRID 221230Notes

Reaction equation

HRID 221230 reaction equation
[CH3:1][N:2]1[CH2:8][CH:7]([CH3:9])[C:6]2[CH:10]=[C:11](Br)[CH:12]=[CH:13][C:5]=2[CH2:4][CH2:3]1.CN1CC(C)C2C=C(I)C=CC=2CC1.CN1CC(C)C2C=C(C(F)(F)F)C=CC=2CC1.CN1CC(CC)C2C=C(C(F)(F)F)C=CC=2CC1.CN1CC(CC)C2C=C([Cl:78])C=CC=2CC1.CN1CC(CC)C2C=C(Br)C=CC=2CC1.CN1CC(CC)C2C=C(I)C=CC=2CC1.CN1CC(C)C2C=C(Cl)C(Cl)=CC=2CC1.CN1CC(CC)C2C=C(Cl)C(Cl)=CC=2CC1.CN1CC(C)C2C=C(Cl)C(F)=CC=2CC1.CN1CC(CC)C2C=C(Cl)C(F)=CC=2CC1>>[CH3:1][N:2]1[CH2:8][CH:7]([CH3:9])[C:6]2[CH:10]=[C:11]([Cl:78])[CH:12]=[CH:13][C:5]=2[CH2:4][CH2:3]1

Participants

12

Reactant 11

HCID 22292781HCID 22292781, compoundHCID 22292786HCID 22292786, compoundHCID 22292802HCID 22292802, compoundHCID 22292807HCID 22292807, compoundHCID 22292809HCID 22292809, compoundHCID 22292814HCID 22292814, compoundHCID 22292816HCID 22292816, compoundHCID 22292825HCID 22292825, compoundHCID 22292828HCID 22292828, compoundHCID 22292829HCID 22292829, compoundHCID 22292841HCID 22292841, compound

Product 1

HCID 9990681HCID 9990681, compound

Procedure

N-methyl-8-Bromo-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine; N-methyl-8-Iodo-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine; N-methyl-8-Trifluoromethyl-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine; N-methyl-8-Trifluoromethyl-1-ethyl-2,3,4,5-tetrahydro-1H-3-benzazepine; N-methyl-8-Chloro-1-ethyl-2,3,4,5-tetrahydro-1H-3-benzazepine; N-methyl-8-Bromo-1-ethyl-2,3,4,5-tetrahydro-1H-3-benzazepine; N-methyl-8-Iodo-1-ethyl-2,3,4,5-tetrahydro-1H-3-benzazepine; N-methyl-7,8-Dichloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine; N-methyl-7,8-Dichloro-1-ethyl-2,3,4,5-tetrahydro-1H-3-benzazepine; N-methyl-8-Chloro-7-fluoro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine; and N-methyl-8-Chloro-7-fluoro-1-ethyl-2,3,4,5-tetrahydro-1H-3-benzazepine; or a pharmaceutically acceptable salt, solvate or hydrate thereof.

Sources & evidence

ORD record
ord-93d3ea781441483bb59149b86c875122
Source dataset
uspto-grants-2012_06
Patent number
US08207158B2

Reaction notes

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