Bromine → HCID 21964198, compound

HRID 2212330Notes

Reaction equation

HRID 2212330 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([C:9](=[O:25])[CH2:10][C:11]2[CH:16]=[CH:15][N:14]=[C:13]([O:17][CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH:12]=2)[CH:5]=[C:6]([CH3:8])[CH:7]=1.[Br:26]Br>C(O)(=O)C>[BrH:26].[Br:26][CH:10]([C:11]1[CH:16]=[CH:15][N:14]=[C:13]([O:17][CH2:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:12]=1)[C:9]([C:4]1[CH:3]=[C:2]([CH3:1])[CH:7]=[C:6]([CH3:8])[CH:5]=1)=[O:25]

Participants

4

Reactant 2

HCID 24408BromineHCID 219642482-[2-(Benzyloxy)pyridin-4-yl]-1-(3,5-dimethylphenyl)ethan-1-one

Product 1

HCID 21964198HCID 21964198, compoundYield 196%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

1-(3,5-Dimethylphenyl)-2-(2-phenylmethyloxy-4-pyridyl)ethanone (3.3 g, 10 mmol) was dissolved in acetic acid (10 mL) and bromine (0.51 mL, 10 mmol) was added to the solution and stirred at room temperature for 30 minutes. The precipitated crude crystals were collected by filtration and washed with diethyl ether to obtain 4.8 g of the title compound (9.8 mmol, yield 98%).

Workup

  1. customThe precipitated crude crystals
  2. filtrationwere collected by filtration
  3. washwashed with diethyl ether

Sources & evidence

ORD record
ord-df5f8e43ff3e4985975659ca89a31115
Source dataset
uspto-grants-2006_09
Patent number
US07101899B1

Reaction notes

Loading…