Lithium Hydroxide → HCID 21963917, compound

Participants

Reaction Steps

To a stirred solution of acetic acid 1-[4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-cyclohexylmethanesulfonyl]-azetidin-3-yl ester (Example 29) (185 mg, 0.33 mmol.) in tetrahydrofuran (10 mL) was added a solution of lithium hydroxide (16 mg, 0.67 mmol.) in water (5 mL) and the mixture stirred for 45 minutes. The solvent was removed in vacuo and the residue diluted with 1N aqueous sodium hydroxide (10 mL) and extracted into ethyl acetate (2×20 mL). The combined organic layers were washed with brine (20 mL), dried (MgSO4) and evaporated to leave the desired compound (171 mg).

Provenance & Evidence