Dicyclohexylcarbodiimide → HCID 21963999, compound

Participants

Reaction Conditions

Reaction Steps

To the product of Example 75 (100 mg, 0.2 mmol) in ethyl acetate (8 mL) was added pentafluorophenol (55 mg, 0.3 mmol). The solution was cooled to 0° C. and dicyclohexylcarbodiimide was added (62 mg, 0.3 mmol). After 2 h the reaction was filtered through Celite® and the filtrate concentrated to give a white solid (130 mg). This was dissolved in a 2 M solution of ammonia in methanol (10 ml) and heated to 50° C. in a sealed tube for 16 h. The mixture was concentrated and the residue purified by flash chromatography on silica eluting with dichloromethane/methanol (9:1) to give a white solid (45 mg).

Provenance & Evidence