Lithium tri-s-butylborohydride → HCID 21963901, compound

Participants

Reaction Conditions

Reaction Steps

The product of Example 94 (150 mg, 0.32 mmol) in tetrahydrofuran (20 mL) at −40° C. was treated dropwise with L-Selectride™ (1M solution in tetrahydrofuran, 0.5 mL, 0.5 mmol). The reaction was stirred at −40° C. for 90 minutes, then quenched by the addition of ethanol (4 drops) then water (10 mL). The mixture was extracted into ethyl acetate (2×50 mL) and the combined organics washed with brine (50 mL), dried (MgSO4) and evaporated to leave a residue which was purified by flash column chromatography on silica eluting with diethyl ether:dichloromethane:iso-hexane 1:2:1, to afford the desired product (107 mg).

Provenance & Evidence