Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) → HCID 21964009, compound

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Reaction Steps

To a stirred solution of the product of Example 150 (73 mg, 0.13 mmol) in acetone (4 mL) and water (1 mL) was added pyridinium p-toluenesulfonate (33 mg, 0.13 mmol) and the mixture refluxed for 3.5 h. The acetone was evaporated and the residue diluted with water (10 mL) and extracted into ethyl acetate (2×10 mL). The combined organic layers were washed with saturated aqueous sodium bicarbonate (10 mL) and brine (20 mL), dried (MgSO4) and evaporated to leave the desired product (64 mg). MS (ES+) 539 ([MNa]+).

Provenance & Evidence