Sulfamide → HCID 21963966, compound

Participants

Reaction Steps

Intermediate R (100 mg, 0.26 mmol in dioxane (4 ml) was treated with sulfamide (125 mg, 1.30 mmol) and heated to reflux for 1 hour, then cooled to room temperature, diluted with ethyl acetate, washed with H2O, dried (MgSO4) and evaporated. Trituration of the residue in ether afforded the desired product (50 mg, 42% yield). 1H NMR (360 MHz, CDCl3) δ 7.40–7.30 (4H, m), 7.09–7.02 (2H, m), 6.90–6.80 (1H, m), 5.51–5.46 (1H, m), 5.14–5.07 (2H, broad, s) 3.70–3.61 (1H, m), 2.60–2.49 (3H, m), 2.19–2.10 (2H, m) and 1.99–1.45 (3H, m). m/z=465, 467 [MH]+

Provenance & Evidence