Triethylamine → HCID 21048957, compound

Participants

Reaction Steps

Intermediate R (102 mg, 0.26 mmol) in dichloromethane (3 ml) was treated with N,N dimethylsulfamoyl chloride (112 μL, 0.80 mmol) followed by triethylamine (74 μl, 0.52 mmol) and dimethylacetamide (1 ml). After 2 hours stirring at room temperature the reaction was diluted with ethyl acetate and washed with H2O and brine, dried (MgSO4) and evaporated to an oil which crystallised on standing. 1H NM (360 MHz, CDCl3) δ 7.39–7.31 (4H, m), 7.09–7.04 (2H, m), 6.89–6.87 (1H, m), 4.56–4.54 (1H, d, J=7.2 Hz), 3.55–3.49 (1H, m), 2.82 (6H, s), 2.61–2.35 (4H, m), 2.06–1.97 (2H, m), 1.57–1.44 (2H, m). m/z=491, 493 [MH]−

Provenance & Evidence