HCID 21049003, compound → HCID 21048999, compound

Participants

Reaction Conditions

Reaction Steps

The product from Example 182 (65 mg, 0.12 mmol) in tetrahydrofuran (10 ml) at 0° C. was treated with methyl magnesium bromide (3M solution in tetrahydrofuran, 0.4 ml). The reaction was stirred at 0° C. for 45 minutes then quenched with NH4Cl solution, extracted into ethyl acetate and evaporated. The residue was purified by chromatography on silica (diethyl ether) to afford the desired compound (18 mg). 1H NMR (360 MHz, CDCl3) δ 7.38–7.31 (4H, m), 7.07–7.06 (2H, m) 6.89–6.80 (1H, m), 4.90–4.98 (1H, d, J=4 Hz), 3.58–3.55 (2H, m), 3.49–3.40 (2H, m), 3.24–3.23 (1H, m), 2.56–2.39 (4H, m), 2.12 (1H, s), 2.04–1.94 (4H, m), 1.52–1.46 (2H, m), 1.45 (3H, s). m/z=571, 573 [MNa]+

Provenance & Evidence