Bromomethyl acetate → HCID 69585023, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of compound 102 (170 mg, 0.5 mmol) and cesium bicarbonate (99 mg, 0.5 mmol) in acetone was added bromomethyl acetate (170 mg, 0.5 mmol) and the mixture stirred at 44° C. temperature for 16 h. After removing the solvent under reduced pressure, the residue was partitioned between ethyl acetate and 10% citric acid. The organic layer was separated, dried over MgSO4 and concentrated to afford the crude product, which was used in the next reaction without further purification.

Provenance & Evidence