HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 3-(3,4-Dimethoxyphenyl)-2-hydrazinyl-2-methylpropanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | HCID 69585034 | HCID 69585034 | — |
| Solvent | Methanol tetrahydrofuran water | HCID 21892291 | — |
| Product | 3-(3,4-Dimethoxyphenyl)-2-hydrazinyl-2-methylpropanoic acid | HCID 13687900 | — |
Reaction Steps
Following the procedure for preparation of compound 119, and treatment of the resulting 120 with 0.33M of LiOH in H2O/MeOH/THF before Boc removal by TFA, provided the title compound 121. 1H NMR (CD3OD, 400 MHz): 1.49 (s, 3H), 3.05 (dd, 2H), 3.80 (2 s, 6H), 6.77–6.92 (m, 3H). MS (ESI) m/z 255.25 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07101912B2 |
| Source dataset | uspto-grants-2006_09 |
| ORD ID | ord-962c9dbb27f04c27a8bba27e0b8ee209 |
| Source note | uspto-grants-2006_09 |