Hydrochloric Acid → HCID 69584947, compound

Participants

Reaction Steps

Compound 155 was dissolved in 2 mL CH2Cl2 and treated with 1 mL trifluoroacetic acid at 0° C. The resulting mixture was allowed to warm to room temperature and stirred for 1 h. The reaction mixture was cooled to 0° C. again and a solution (1 mL) of 4 N HCl in dioxane was added. After stirring at room temperature for 2 h, the solvent was removed in vacuo. The crude residue was purified by reverse phase LC/MS to afford 103 mg (24% overall yield) of the title compound. 1H-NMR (400 MHz, CD3OD): δ 7.14–7.22 (m, 3H), 4.49–4.69 (Abq, J=62.8, 14.8, 2H), 4.24–4.29 (m, 4H), 3.03–3.13 (q, J=13.6 Hz), 1.33 (t, J=6.0 Hz, 6H). MS (ESI) m/z 429.2 (M+H+).

Provenance & Evidence