HCID 21964606, compound → HCID 69584954, compound

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Reaction Steps

Following the procedure described for preparation of compound 229, and substituting tert-butyl bromomethyl acetate with 2,4-dimethoxybenzyl γ-bromobutyrate, provided the title compound (41% over 2 steps) as a colorless thick liquid. 1H NMR (400 MHz, CD3OD): δ1.45 (3H, s), 1.95 (2H, q), 2.35 (2H, t), 2.86(2H, m), 4.21 (2H, m), 6.46 (1H, dd), 6.56(1H, d), 6.68 (1H, d). MS (ESI) m/z 313.21 (M+H+) and 311.18 (M−H−).

Provenance & Evidence