Ammonia → 2-Aminoadenosine

Participants

Reaction Steps

This variation of the procedures of Robins, et al. supra, eliminated the need to utilize liquid ammonia in the reaction mixture since the ammonia molecule is generation in situ from the silazane reagent and the water of hydration of the guanosine hydrate starting material. Further, the use of chlorotrimethylsilane was not necessary nor was it necessary to conduct the reaction under anhydrous conditions, do a preliminary evaportaion, or open and re-seal the Parr bomb under a dry nitrogen atmosphere.

Provenance & Evidence